产品名称
FBXO2 Rabbit Polyclonal Antibody
蛋白名称
F-box only protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26232
Human Swissprot No.
Q9UK22
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UK22
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230904
Mouse Swissprot No.
Q80UW2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80UW2/entry
特异性
This antibody detects endogenous levels of FBXO2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Microsome membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
