产品名称
DOCK3; MOCA Rabbit Polyclonal Antibody
蛋白名称
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1795
Human Swissprot No.
Q8IZD9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IZD9
Mouse Swissprot No.
Q8CIQ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIQ7/entry
特异性
This antibody detects endogenous levels of DOCK3; MOCA at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
功能
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).
