产品名称
MEX3C Rabbit Polyclonal Antibody
基因名称
MEX3C RKHD2 RNF194 BM-013
蛋白名称
RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 6.3.2.-) (RING finger and KH domain-containing protein 2) (RING finger protein 194)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51320
Human Swissprot No.
Q5U5Q3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5U5Q3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=240396
Mouse Swissprot No.
Q05A36
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q05A36/entry
特异性
This antibody detects endogenous levels of MEX3C at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.
细胞定位
Cytoplasm . Nucleus . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
功能
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
