产品名称
TRAM1 Rabbit Polyclonal Antibody
蛋白名称
Translocating chain-associated membrane protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23471
Human Swissprot No.
Q15629
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15629
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72265
Mouse Swissprot No.
Q91V04
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91V04/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=312903
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XI41/entry
特异性
This antibody detects endogenous levels of TRAM1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel . Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER . May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport . Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane . Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane . Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome . ; (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells.
