产品名称
HIC1 Rabbit Polyclonal Antibody
蛋白名称
Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3090
Human Swissprot No.
Q14526
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14526
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15248
Mouse Swissprot No.
Q9R1Y5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R1Y5/entry
特异性
This antibody detects endogenous levels of HIC1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
功能
Transcriptional repressor . Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' . May act as a tumor suppressor . Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses . The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 . In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells . Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes . Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex . Probably represses transcription of ACKR3, FGFBP1 and EFNA1 .
