产品名称
MUS81 Rabbit Polyclonal Antibody
蛋白名称
Crossover junction endonuclease MUS81 (EC 3.1.22.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80198
Human Swissprot No.
Q96NY9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96NY9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71711
Mouse Swissprot No.
Q91ZJ0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91ZJ0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293678
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KM32/entry
特异性
This antibody detects endogenous levels of MUS81 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleolus . Recruited to foci of DNA damage in S-phase cells.
功能
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. Plays an essential role in mitosis for the processing of stalled or collapsed replication forks .
