产品名称
GGA2 Rabbit Polyclonal Antibody
蛋白名称
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23062
Human Swissprot No.
Q9UJY4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UJY4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74105
Mouse Swissprot No.
Q6P5E6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P5E6/entry
特异性
This antibody detects endogenous levels of GGA2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein .
功能
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network .
