产品名称
FUSIP1 Rabbit Polyclonal Antibody
基因名称
SRSF10 FUSIP1 FUSIP2 SFRS13A TASR
蛋白名称
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100996657
Human Swissprot No.
O75494
Human Swissprot Link
https://www.uniprot.org/uniprot/O75494
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14105
Mouse Swissprot No.
Q9R0U0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0U0/entry
特异性
This antibody detects endogenous levels of FUSIP1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus speckle . Cytoplasm .
功能
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing . Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 . Required for splicing repression in M-phase cells and after heat shock . Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator .
