产品名称
PTPRD Rabbit Polyclonal Antibody
蛋白名称
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P23468
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23468/entry
Mouse Swissprot No.
Q64487
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64487
免疫原
Synthesized peptide derived from human protein . at AA range: 510-590
特异性
PTPRD Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010],
组织表达
Brain,PCR rescued clones,Placenta,
细胞定位
Membrane; Single-pass type I membrane protein.
功能
alternative products:Additional isoforms seem to exist,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,PTM:A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 8 fibronectin type-III domains.,subunit:Interacts with PPFIA1, PPFIA2 and PPFIA3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
