产品名称
MKRN2 Rabbit Polyclonal Antibody
蛋白名称
Probable E3 ubiquitin-protein ligase makorin-2 (EC 6.3.2.-) (RING finger protein 62)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23609
Human Swissprot No.
Q9H000
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H000
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67027
Mouse Swissprot No.
Q9ERV1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERV1/entry
特异性
This antibody detects endogenous levels of MKRN2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level) (PubMed:28008940). Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen (PubMed:11597136).
细胞定位
Cytoplasm . Nucleus .
功能
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity).
