产品名称
CPNE1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8904
Human Swissprot No.
Q99829
Human Swissprot Link
https://www.uniprot.org/uniprot/Q99829
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=266692
Mouse Swissprot No.
Q8C166
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C166/entry
特异性
This antibody detects endogenous levels of CPNE1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood (PubMed:12949241).
细胞定位
Nucleus . Cytoplasm . Cell membrane . Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). .
功能
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes . Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner . Exhibits calcium-dependent phospholipid binding properties . Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner . May recruit target proteins to the cell membrane in a calcium-dependent manner . May function in membrane trafficking . Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit . Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL .
