产品名称
Plexin B2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23654
Human Swissprot No.
O15031
Human Swissprot Link
https://www.uniprot.org/uniprot/O15031
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140570
Mouse Swissprot No.
B2RXS4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/B2RXS4/entry
特异性
This antibody detects endogenous levels of Plexin B2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton . Plays a role in axon guidance, invasive growth and cell migration . May modulate the activity of RAC1 and CDC42 (By similarity).
