产品名称
VPS52 Rabbit Polyclonal Antibody
蛋白名称
Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6293
Human Swissprot No.
Q8N1B4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N1B4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=224705
Mouse Swissprot No.
Q8C754
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C754/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25218
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O55166/entry
特异性
This antibody detects endogenous levels of VPS52 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein. Endosome membrane ; Peripheral membrane protein. Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). .
功能
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD . Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane .
