产品名称
GM2A Rabbit Polyclonal Antibody
蛋白名称
Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Shingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2760
Human Swissprot No.
P17900
Human Swissprot Link
https://www.uniprot.org/uniprot/P17900
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14667
Mouse Swissprot No.
Q60648
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60648/entry
特异性
This antibody detects endogenous levels of GM2A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity .
