产品名称
RRAS2 Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein R-Ras2 (Ras-like protein TC21) (Teratocarcinoma oncogene)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P62070
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62070/entry
Mouse Swissprot No.
P62071
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62071
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
RRAS2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010],
组织表达
Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side. Golgi apparatus membrane ; Lipid-anchor .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Tight junction;Regulates Actin and Cytoskeleton;
功能
disease:Defects in RRAS2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.,PTM:May be post-translationally modified by both palmitoylation and polyisoprenylation.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).,tissue specificity:Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
