产品名称
RUNX1T1 Rabbit Polyclonal Antibody
基因名称
RUNX1T1 AML1T1 CBFA2T1 CDR ETO MTG8 ZMYND2
蛋白名称
Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=862
Human Swissprot No.
Q06455
Human Swissprot Link
https://www.uniprot.org/uniprot/Q06455
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12395
Mouse Swissprot No.
Q61909
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61909/entry
特异性
This antibody detects endogenous levels of RUNX1T1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
细胞定位
Nucleus . Colocalizes with ATN1 in discrete nuclear dots.
功能
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Can repress the expression of MMP7 in a ZBTB33-dependent manner . Can repress transactivation mediated by TCF12 . Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal .
