产品名称
SIN3A Rabbit Polyclonal Antibody
蛋白名称
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25942
Human Swissprot No.
Q96ST3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96ST3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466
Mouse Swissprot No.
Q60520
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60520/entry
特异性
This antibody detects endogenous levels of SIN3A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
细胞定位
Nucleus . Nucleus, nucleolus . Recruited to the nucleolus by SAP30L.
功能
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
