产品名称
NDST1 Rabbit Polyclonal Antibody
蛋白名称
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.-)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3340
Human Swissprot No.
P52848
Human Swissprot Link
https://www.uniprot.org/uniprot/P52848
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15531
Mouse Swissprot No.
Q3UHN9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UHN9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29633
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q02353/entry
特异性
This antibody detects endogenous levels of NDST1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expression is most abundant in heart, liver and pancreas.
细胞定位
[Isoform 1]: Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .; [Isoform 3]: Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein .
功能
[Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate . Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis . Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan . ; [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates.
