产品名称
CAPRIN2 Rabbit Polyclonal Antibody
基因名称
CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140
蛋白名称
Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65981
Human Swissprot No.
Q6IMN6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6IMN6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=232560
Mouse Swissprot No.
Q05A80
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q05A80/entry
特异性
This antibody detects endogenous levels of CAPRIN2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in all tissues tested with highest levels of expression in brain and spleen.
细胞定位
[Isoform 1]: Cytoplasm.; [Isoform 2]: Mitochondrion. Cytoplasm. Expressed throughout the cytoplasm.; [Isoform 5]: Mitochondrion. Colocalizes with aggregated mitochondria.; Cell membrane ; Peripheral membrane protein .
功能
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway . Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling . May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation . May be involved in apoptosis .
