产品名称
TRIM8 Rabbit Polyclonal Antibody
蛋白名称
Probable E3 ubiquitin-protein ligase TRIM8 (EC 6.3.2.-) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (Tripartite motif-containing protein 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81603
Human Swissprot No.
Q9BZR9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BZR9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93679
Mouse Swissprot No.
Q99PJ2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99PJ2/entry
特异性
This antibody detects endogenous levels of TRIM8 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. .
功能
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response . Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 . Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B . Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus . Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction .
