产品名称
BANP Rabbit Polyclonal Antibody
蛋白名称
Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54971
Human Swissprot No.
Q8N9N5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N9N5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53325
Mouse Swissprot No.
Q8VBU8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBU8/entry
特异性
This antibody detects endogenous levels of BANP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Down-regulated in breast cancer cell lines.
功能
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).
