产品名称
CCDC120 Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 120
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=90060
Human Swissprot No.
Q96HB5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96HB5
特异性
This antibody detects endogenous levels of CCDC120 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm . Cell projection, neuron projection . Cell projection, growth cone . Endosome . Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (PubMed:28422092). Recruited to subdistal appendages by ODF2 (PubMed:28422092). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (PubMed:25326380). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (PubMed:25326380). .
功能
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells . Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly . Recruits NIN and CEP170 to centrosomes . Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.
