产品名称
RIPK5 Rabbit Polyclonal Antibody
基因名称
DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P
蛋白名称
Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25778
Human Swissprot No.
Q6XUX3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6XUX3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=213452
Mouse Swissprot No.
Q6XUX1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XUX1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304791
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6XUX2/entry
特异性
This antibody detects endogenous levels of RIPK5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540).
细胞定位
Cytoplasm . Cell membrane . Apical cell membrane . Basolateral cell membrane . Cell junction . Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. .
功能
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation . Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death . In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types .
