产品名称
TRMT61B Rabbit Polyclonal Antibody
蛋白名称
Potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61B (EC 2.1.1.220)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55006
Human Swissprot No.
Q9BVS5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BVS5
特异性
This antibody detects endogenous levels of TRMT61B at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) . Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function . In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation .
