产品名称
SHANK1 Rabbit Polyclonal Antibody
蛋白名称
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50944
Human Swissprot No.
Q9Y566
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y566
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=243961
Mouse Swissprot No.
D3YZU1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/D3YZU1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78957
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV48/entry
特异性
This antibody detects endogenous levels of SHANK1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
细胞定位
Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Colocalizes with alpha-latrotoxin receptor 1. .
功能
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
