产品名称
IYD Rabbit Polyclonal Antibody
蛋白名称
Iodotyrosine dehalogenase 1 (IYD-1) (EC 1.22.1.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=389434
Human Swissprot No.
Q6PHW0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6PHW0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70337
Mouse Swissprot No.
Q9DCX8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DCX8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308129
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BK17/entry
特异性
This antibody detects endogenous levels of IYD at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
细胞定位
Cell membrane ; Single-pass membrane protein . Cytoplasmic vesicle membrane .
功能
Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine . During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) . The scavanged iodide can then reenter the hormone-producing pathways . Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine .
