产品名称
SCO1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6341
Human Swissprot No.
O75880
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75880/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/52892
Mouse Swissprot No.
Q5SUC9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5SUC9
免疫原
Synthesized peptide derived from human SCO1 AA range: 223-273
特异性
This antibody detects endogenous levels of SCO1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
细胞定位
Mitochondrion . Mitochondrion inner membrane ; Single-pass membrane protein .
功能
disease:Defects in SCO1 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110]. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood.,function:Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.,similarity:Belongs to the SCO1/2 family.,subunit:Homodimer.,tissue specificity:Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
