产品名称
GLRA3 Rabbit Polyclonal Antibody
蛋白名称
Glycine receptor subunit alpha-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8001
Human Swissprot No.
O75311
Human Swissprot Link
https://www.uniprot.org/uniprot/O75311
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110304
Mouse Swissprot No.
Q91XP5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XP5/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P24524/entry
特异性
This antibody detects endogenous levels of GLRA3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely distributed throughout the central nervous system.
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell junction, synapse . Cell membrane ; Multi-pass membrane protein . Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. .
功能
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).
