产品名称
GIYD2 Rabbit Polyclonal Antibody
基因名称
SLX1A GIYD1 SLX1; SLX1B GIYD2 SLX1
蛋白名称
Structure-specific endonuclease subunit SLX1 (EC 3.6.1.-) (GIY-YIG domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=548593
Human Swissprot No.
Q9BQ83
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BQ83
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75764
Mouse Swissprot No.
Q8BX32
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BX32/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293489
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PQP5/entry
特异性
This antibody detects endogenous levels of GIYD2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
