产品名称
PITRM1 Rabbit Polyclonal Antibody
蛋白名称
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10531
Human Swissprot No.
Q5JRX3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5JRX3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69617
Mouse Swissprot No.
Q8K411
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K411/entry
特异性
This antibody detects endogenous levels of PITRM1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
细胞定位
Mitochondrion . Mitochondrion matrix .
功能
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing . Has an ATP-independent activity . Specifically cleaves peptides in the range of 5 to 65 residues . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference . Degrades the transit peptides of mitochondrial proteins after their cleavage . Also degrades other unstructured peptides . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion . It is a highly efficient protease, at least toward amyloid-beta protein 40 . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently . It is also able to degrade amyloid-beta protein 42 .
