产品名称
TEX15 Rabbit Polyclonal Antibody
蛋白名称
Testis-expressed sequence 15 protein (Cancer/testis antigen 42) (CT42)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56154
Human Swissprot No.
Q9BXT5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BXT5
特异性
This antibody detects endogenous levels of TEX15 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in testis, predominantly in germ cells (PubMed:11279525, PubMed:26199321). Low expression, if any, in ovary (PubMed:11279525, PubMed:26199321). Also expressed in several cancers (PubMed:12704671).
细胞定位
Cytoplasm . Nucleus .
功能
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity). Not required for piRNA biosynthesis (By similarity).
