产品名称
THOC2 Rabbit Polyclonal Antibody
蛋白名称
THO complex subunit 2 (Tho2) (hTREX120)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57187
Human Swissprot No.
Q8NI27
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NI27
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=331401
Mouse Swissprot No.
B1AZI6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/B1AZI6/entry
特异性
This antibody detects endogenous levels of THOC2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the hippocampus and the cerebral cortex.
细胞定位
Nucleus . Nucleus speckle .
功能
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.
