产品名称
AKAP8L Rabbit Polyclonal Antibody
基因名称
AKAP8L NAKAP NAKAP95 HRIHFB2018
蛋白名称
A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26993
Human Swissprot No.
Q9ULX6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9ULX6
Mouse Swissprot No.
Q9R0L7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R0L7/entry
特异性
This antibody detects endogenous levels of AKAP8L at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed. Expressed in the brain cortex (at protein level).
细胞定位
Nucleus . Nucleus matrix . Nucleus speckle . Nucleus, PML body . Cytoplasm . Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601). .
功能
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing . ; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. ; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. ; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
