产品名称
VPS36 Rabbit Polyclonal Antibody
基因名称
VPS36 C13orf9 EAP45 CGI-145
蛋白名称
Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51028
Human Swissprot No.
Q86VN1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86VN1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70160
Mouse Swissprot No.
Q91XD6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XD6/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0C0A2/entry
特异性
This antibody detects endogenous levels of VPS36 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm. Endosome. Late endosome . Membrane. Nucleus . Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. .
功能
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
