产品名称
RNF26 Rabbit Polyclonal Antibody
蛋白名称
RING finger protein 26
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79102
Human Swissprot No.
Q9BY78
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BY78
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=213211
Mouse Swissprot No.
Q8BUH7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BUH7/entry
特异性
This antibody detects endogenous levels of RNF26 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Up-regulated in several cancer cell lines.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud . Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 . Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport . Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING . Also required to limit type I interferon response by promoting autophagic degradation of IRF3 .
