产品名称
MYBBP1A Rabbit Polyclonal Antibody
蛋白名称
Myb-binding protein 1A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10514
Human Swissprot No.
Q9BQG0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BQG0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18432
Mouse Swissprot No.
Q7TPV4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TPV4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60571
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35821/entry
特异性
This antibody detects endogenous levels of MYBBP1A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleolus . Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. .
功能
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 .
