产品名称
SYNJ1 Rabbit Polyclonal Antibody
蛋白名称
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8867
Human Swissprot No.
O43426
Human Swissprot Link
https://www.uniprot.org/uniprot/O43426
Mouse Swissprot No.
Q8CHC4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHC4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85238
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62910/entry
特异性
This antibody detects endogenous levels of SYNJ1 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.
细胞定位
Cytoplasm, perinuclear region .
功能
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate . Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
