产品名称
RyDEN Rabbit Polyclonal Antibody
蛋白名称
UPF0515 protein C19orf66
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55337
Human Swissprot No.
Q9NUL5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NUL5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319278
Mouse Swissprot No.
Q8CAK3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CAK3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=500956
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RJN4/entry
特异性
This antibody detects endogenous levels of RyDEN at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Cytoplasm, P-body . Predominantly found in the cytoplasm (PubMed:26735137). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). .
功能
Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site . Regulates HIV1 GAG-POL expression by inhibiting -1PRF . Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Interrupts also Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway . Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus . Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA . ; Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes.
