产品名称
TRIM6 Rabbit Polyclonal Antibody
蛋白名称
Tripartite motif-containing protein 6 (RING finger protein 89)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117854
Human Swissprot No.
Q9C030
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9C030
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94088
Mouse Swissprot No.
Q8BGE7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGE7/entry
特异性
This antibody detects endogenous levels of TRIM6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway . In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response . Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity).
