产品名称
ASL Rabbit Polyclonal Antibody
蛋白名称
Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=435
Human Swissprot No.
P04424
Human Swissprot Link
https://www.uniprot.org/uniprot/P04424
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109900
Mouse Swissprot No.
Q91YI0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YI0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59085
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P20673/entry
特异性
This antibody detects endogenous levels of ASL at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues . Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway .
