产品名称
HIP1 Rabbit Polyclonal Antibody
蛋白名称
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3092
Human Swissprot No.
O00291
Human Swissprot Link
https://www.uniprot.org/uniprot/O00291
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=215114
Mouse Swissprot No.
Q8VD75
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VD75/entry
特异性
This antibody detects endogenous levels of HIP1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
细胞定位
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
功能
Plays a role in clathrin-mediated endocytosis and trafficking . Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription . May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway . Binds 3-phosphoinositides (via ENTH domain) . May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis . May play a functional role in the cell filament networks . May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors .
