产品名称
RIC8A Rabbit Polyclonal Antibody
蛋白名称
Synembryn-A (Protein Ric-8A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60626
Human Swissprot No.
Q9NPQ8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NPQ8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=101489
Mouse Swissprot No.
Q3TIR3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TIR3/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q80ZG1/entry
特异性
This antibody detects endogenous levels of RIC8A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cell membrane . Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). .
功能
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
