产品名称
POLE3 Rabbit Polyclonal Antibody
蛋白名称
DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54107
Human Swissprot No.
Q9NRF9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NRF9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59001
Mouse Swissprot No.
Q9JKP7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKP7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100362333
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q642A5/entry
特异性
This antibody detects endogenous levels of POLE3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
功能
Accessory component of the DNA polymerase epsilon complex . Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 . Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex .
