产品名称
ARIH2 Rabbit Polyclonal Antibody
基因名称
ARIH2 ARI2 TRIAD1 HT005
蛋白名称
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 6.3.2.-) (Triad1 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10425
Human Swissprot No.
O95376
Human Swissprot Link
https://www.uniprot.org/uniprot/O95376
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23807
Mouse Swissprot No.
Q9Z1K6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1K6/entry
特异性
This antibody detects endogenous levels of ARIH2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with higher expression in granulocytes.
细胞定位
Nucleus . Cytoplasm .
功能
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 . Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex . Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination . May play a role in myelopoiesis .
