产品名称
RB33B Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Rab-33B
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H082
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H082/entry
Mouse Swissprot No.
O35963
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35963
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
RB33B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016],
组织表达
Brain,Testis,Tongue,
细胞定位
Golgi apparatus membrane ; Lipid-anchor . Golgi apparatus, cis-Golgi network . Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm. .
功能
function:Protein transport. Probably involved in vesicular traffic.,similarity:Belongs to the small GTPase superfamily. Rab family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
