产品名称
OSBPL3 Rabbit Polyclonal Antibody
基因名称
OSBPL3 KIAA0704 ORP3 OSBP3
蛋白名称
Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26031
Human Swissprot No.
Q9H4L5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H4L5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71720
Mouse Swissprot No.
Q9DBS9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DBS9/entry
特异性
This antibody detects endogenous levels of OSBPL3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland. Expressed at low concentration in whole brain, esophagus, duodenum, ileocecum, colon, skeletal muscle, bone marrow, placenta and mammary gland (PubMed:14593528). Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung (PubMed:12590732).
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Cell projection, filopodium tip . Nucleus membrane ; Peripheral membrane protein . Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum. .
功能
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes . Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface . With VAPA, may regulate ER morphology . Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion . Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 . Also binds 25-hydroxycholesterol and cholesterol .
