产品名称
NUP50 Rabbit Polyclonal Antibody
基因名称
NUP50 NPAP60L PRO1146
蛋白名称
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10762
Human Swissprot No.
Q9UKX7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UKX7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18141
Mouse Swissprot No.
Q9JIH2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JIH2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25497
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08587/entry
特异性
This antibody detects endogenous levels of NUP50 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
细胞定位
Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065). Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). .
功能
Component of the nuclear pore complex that has a direct role in nuclear protein import . Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling . Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity).
