产品名称
ZBTB38 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger and BTB domain-containing protein 38
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=253461
Human Swissprot No.
Q8NAP3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NAP3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315936
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EXX3/entry
特异性
This antibody detects endogenous levels of ZBTB38 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome . Localizes to chromocenters. .
功能
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner . Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication . Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).
