产品名称
TIMELESS Rabbit Polyclonal Antibody
基因名称
TIMELESS TIM TIM1 TIMELESS1
蛋白名称
Protein timeless homolog (hTIM)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8914
Human Swissprot No.
Q9UNS1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UNS1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21853
Mouse Swissprot No.
Q9R1X4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R1X4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83508
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2Y1/entry
特异性
This antibody detects endogenous levels of TIMELESS at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
细胞定位
Nucleus . Chromosome . In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. .
功能
Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock . Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress . TIMELESS promotes TIPIN nuclear localization . Involved in cell survival after DNA damage or replication stress by promoting DNA repair . In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 . May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light . Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock . Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus . May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity).
