产品名称
RAB32 Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Rab-32
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13637
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13637/entry
Mouse Swissprot No.
Q9CZE3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZE3
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
RAB32 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015],
组织表达
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
细胞定位
Mitochondrion . Mitochondrion outer membrane ; Lipid-anchor . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Melanosome membrane . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). .
功能
function:Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission.,similarity:Belongs to the small GTPase superfamily. Rab family.,tissue specificity:Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
